Fate of preformed immune complexes in rabbits and rhesus monkeys.

摘要: Preformed soluble immune complexes injected into rabbits or rhesus monkeys showed similar characteristics of disappearance from circulation. Complexes made with intact γG-antibodies and exceeding the Ag2Ab2 lattice formation were rapidly removed by hepatic RES. These fixed complement effectively in vitro. Their uptake was not dependent upon circulating components, since their accumulation liver unchanged depleted rabbits. Similar antigen-antibody reduced alkylated ineffectively possessed different taken up liver, regardless degree formation. Both vitro vivo studies failed to suggest any role for adherence receptor on primate erythrocytes handling composed BSA this antigen.