Response of primary culture of human ovarian cancer cells to chemotherapy: In vitro individualized therapy

摘要: Objective: This study focused on whether primary cultures of ovarian cancer (OC) cells established from ascites can be used to evaluate response chemotherapeutic agents and if curcumin could enhance the efficacy these agents. Materials Methods: We five ascitic OC patients treated them with curcumin, carboplatin, paclitaxel singly in combinations. The percentage apoptotic was determined by flow cytometry. Results: There a wide variation individual treatment Curcumin itself as good carboplatin or inducing apoptosis cells. not able affect mediated cell killing. However, combination additive equally effective paclitaxel. A also found and, fact, turned out best that gave highest vitro. Conclusion: highlights fact detect help individualize offered patients.