Microglia in the Aging Retina
作者： Marcus Karlstetter , Thomas Langmann
DOI: 10.1007/978-1-4614-3209-8_27
关键词: Population 、 Retina 、 Retinal Disorder 、 Retinal degeneration 、 Retinal 、 Neuroscience 、 Microglia 、 Neuroprotection 、 Inflammation 、 Medicine
摘要: In the healthy retina, microglial cells represent a self-renewing population of innate immune cells, which constantly survey their microenvironment. Equipped with receptors, cell detects subtle cellular damage and rapidly responds activation, migration, increased phagocytic activity. While involvement has been well characterized in monogenic retinal disorders, it is still unclear how they contribute to onset aging disorders including age-related macular degeneration (AMD). There evidence, that activation not solely secondary manifestation tissue disorders. Thus, work rodent human retina suggests long-lived genetically predisposed microglia transform into dystrophic state, loss neuroprotective functions. this concept, malfunction can trigger chronic low-grade inflammatory environment favors progression degeneration.
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