Adoptive T cell immunotherapy strategies for the treatment of patients with ovarian cancer.

摘要: Ovarian cancer is the leading cause of death among gynecological malignances. Despite initial successful multimodality therapy with cytoreductive surgery and subsequent combination chemotherapy, most patients advanced disease will ultimately relapse become incurable. For this reason novel therapeutic approaches for treatment malignancy are urgently needed. Adoptive transfer genetically modified autologous tumor-reactive T cells a promising antitumor many cancers. may be ex vivo to express chimeric antigen receptors (CARs), which artificial cell targeted specific tumor antigens. The resulting thus programmed recognize cells. carcinomas in particular appear suited approach based on fact that these tumors relatively immunogenic, inducing an endogenous response. Furthermore, degree mediated immune response evident correlates long-term patient prognosis following chemotherapy. To end, adoptive immunotherapy strategies ovarian particularly currently being investigated at several centers both pre-clinical clinical settings.