Tumor infiltrating lymphocytes in ovarian cancer

摘要: The accumulation of tumor infiltrating lymphocytes (TILs) in ovarian cancer is prognostic for increased survival while increases immunosuppressive regulatory T-cells (Tregs) are associated with poor outcomes. Approaches that bolster tumor-reactive TILs may limit progression. However, identifying has been challenging, though adoptive TIL therapy patients encouraging. Other forms immunomodulation remain under investigation including Treg depletion, antibody-based checkpoint modification, activation and amplification using dendritic cells, antigen presenting cells or IL-2 cytokine culture, adjuvant injections, gene-engineered T-cells. Many approaches to manipulation inhibit progression preclinical clinical studies as monotherapy. Here, we review the impact attempts mobilize halt We conclude effective at brink translation optimal activity require combined methodologies deliver clinically-relevant treatment.