Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1
作者： Nancy H. Jones , Martha L. Clabby , Deno P. Dialynas , Huei-Jen S. Huang , Leonard A. Herzenberg
DOI: 10.1038/323346A0
关键词: Molecular mass 、 Cell surface receptor 、 Molecular biology 、 Complementary DNA 、 Glycoprotein 、 Protein primary structure 、 Signal peptide 、 Biology 、 Biochemistry 、 Extracellular 、 Receptor
摘要: The Tl/Leu-l/CD5 molecule, a human T-cell surface glycoprotein of relative molecular mass (Mr) 67,0001–3, has been implicated in the proliferative response activated T cells4 and helper function5. A similar involvement proliferation reported for Ly-1 (refs 6–8), murine homologue T1 (ref. 9). Here we report complete amino-acid sequence precursor molecule deduced from complementary DNA clones. protein contains classical signal peptide; 347-amino-acid extracellular segment; transmembrane region; 93-amino-acid intracellular segment. segment many cysteine residues is composed two related structural domains separated by proline/threonine-rich region. features characteristic other receptor molecules.
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