Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator

摘要: Abstract Trans sodium crocetinate (TSC) is a synthetic small-molecule antioxidant that has the ability to enhance oxygen diffusion hypoxic tissue. Because TSC promising drug candidate treat acute ischemic stroke (AIS), we tested hypothesis may be neuroprotective following cerebral ischemia using rabbit small clot embolic model (RSCEM) clinical rating scores as endpoint. or saline was administered IV injection of blood clots into brain vasculature. Behavior measured 24 h embolization in order calculate effective dose (P 50 ) produces neurological deficits 50% rabbits. A treatment considered beneficial if it significantly increases P compared control. (0.25 mg/kg) given 5 60 min ( p values by 104% and 181%; but not when 3 post-embolization (48% increase,  > 0.05). tPA (3.3 mg/kg) produced significant increase 1, embolization. In combination studies, 1 either embolization, group were increased 291% 140%, respectively. addition, plus value 90%. There no effects  > 0.05) alone with on intracerebral hemorrhage incidence. This study suggests used for AIS before concomitant improve therapeutic window therapy up Moreover, appears can tPA, since did result any change