Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging.
作者： Satoshi SUDA , Hironaka IGARASHI , Yasushi ARAI , Jyun ANDOU , Tetsuro CHISHIKI
DOI: 10.2176/NMC.47.197
关键词:
摘要: The anti-edema effect of edaravone, a free radical scavenger, was evaluated by magnetic resonance imaging in six patients with extensive hemispheric ischemic stroke. T(2) relaxation time the infarct core, boundary zone infarct, and noninfarcted hemisphere were calculated, mapping performed before after edaravone administration. Edaravone administration significantly decreased mean from 121.5 +/- 9.2 (mean standard deviation) to 114.5 9.9 msec (p = 0.008), but not core 142.3 13.4 142.2 18.5 0.97) or 93.0 3.7 93.1 3.8 0.91). subtraction map clearly demonstrated shortened infarct. present results indicate that can salvage is useful cytoprotective agent.
sci-hub.se 参考文章(26)
Igor Klatzo, Presidental address. Neuropathological aspects of brain edema. Journal of Neuropathology and Experimental Neurology. ,vol. 26, pp. 1- 14 ,(1967) , 10.1097/00005072-196701000-00001
T Watanabe, M Egawa, Effects of an antistroke agent MCl-186 on cerebral arachidonate cascade. Journal of Pharmacology and Experimental Therapeutics. ,vol. 271, pp. 1624- 1629 ,(1994)
J. T. MacDonald, D. L. Uden, Intravenous glycerol and mannitol therapy in children with intracranial hypertension Neurology. ,vol. 32, pp. 437- 437 ,(1982) , 10.1212/WNL.32.4.437
M Kaste, O Waltimo, Prognosis of patients with middle cerebral artery occlusion. Stroke. ,vol. 7, pp. 482- 485 ,(1976) , 10.1161/01.STR.7.5.482
Pak H. Chan, Role of Oxidants in Ischemic Brain Damage Stroke. ,vol. 27, pp. 1124- 1129 ,(1996) , 10.1161/01.STR.27.6.1124
Masanori Sakamaki, Hironaka Igarashi, Yutaka Nishiyama, Hiroshi Hagiwara, Jun Ando, Tetsurou Chishiki, Brian C. Curran, Yasuo Katayama, Effect of glycerol on ischemic cerebral edema assessed by magnetic resonance imaging. Journal of the Neurological Sciences. ,vol. 209, pp. 69- 74 ,(2003) , 10.1016/S0022-510X(02)00465-3
J W Schmidley, Free radicals in central nervous system ischemia. Stroke. ,vol. 21, pp. 1086- 1090 ,(1990) , 10.1161/01.STR.21.7.1086
Hideo Shichinohe, Satoshi Kuroda, Hiroshi Yasuda, Tatsuya Ishikawa, Masaru Iwai, Masatsugu Horiuchi, Yoshinobu Iwasaki, Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia Brain Research. ,vol. 1029, pp. 200- 206 ,(2004) , 10.1016/J.BRAINRES.2004.09.055
T. Heinsius, J. Bogousslavsky, G. Van Melle, Large infarcts in the middle cerebral artery territory Etiology and outcome patterns Neurology. ,vol. 50, pp. 341- 350 ,(1998) , 10.1212/WNL.50.2.341
Andreas Bacher, Jingna Wei, Marjorie R. Grafe, Michael J. Quast, Mark H. Zornow, Serial determinations of cerebral water content by magnetic resonance imaging after an infusion of hypertonic saline. Critical Care Medicine. ,vol. 26, pp. 108- 114 ,(1998) , 10.1097/00003246-199801000-00024