Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane

作者： MB Plotnikov , AE Prosenko , VI Smol’yakova , IS Ivanov , GA Chernysheva

关键词: Rat brain 、 Ischemia 、 Reference drug 、 In vitro 、 Pharmacology 、 Biochemistry 、 Lipid peroxidation 、 Antioxidant 、 High activity 、 Chemistry 、 In vivo 、 Drug discovery

摘要: The new multifunctional antioxidant 3,5-dimethyl-4-hydroxybenzylthiododecane (DHBD) demonstrated high activity both in vitro and vivo. Experiments showed that the of DHBD significantly exceeded well-known reference drug ionol. A course administration (100 mg/kg, p.o.) decreased content lipid peroxidation products rat brain on model long-term incomplete cerebral ischemia.

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Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane

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Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane

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