Activation of mucosal mast cells promotes inflammation-related colon cancer development through recruiting and modulating inflammatory CD11b(+)Gr1(+) cells.
作者： Lingzhi Xu , Hong-Gan Yi , Zhiyuan Wu , Wenxiao Han , Kun Chen
DOI: 10.1016/J.CANLET.2015.05.014
关键词: Intestinal mucosa 、 T cell 、 Cancer research 、 Biology 、 Tumor microenvironment 、 Mast cell 、 Colitis 、 Connective tissue 、 Immunology 、 Inflammation 、 Epithelium
摘要: Mast cells (MCs) have been reported to be one of the important immunoregulatory in promoting development colitis-related colon cancer (CRC). It is not clear which MC subtypes play critical roles CRC progression from colitis because mucosal mast (MMCs) are distinct connective tissue (CTMCs) maintaining intestinal barrier function under homeostatic and inflammatory conditions. In current study, we found that MMC numbers gene expressions MMC-specific proteases increased significantly an induced murine model. The production cell protease-1 (mMCP-1) after activation only resulted accumulation CD11b(+)Gr1(+) tissues but also modulated activities support tumor growth inhibit T activation. Blocking activity mice had developed epithelium dysplasia, infiltration was reduced inhibited. Our results suggest recruited promote MMCs can potential therapeutic targets for prevention development.
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