The Role of Mast Cells in Molding the Tumor Microenvironment.

作者: A. Rigoni , M. P. Colombo , C. Pucillo

DOI: 10.1007/S12307-014-0152-8

关键词:

摘要: Mast cells (MCs) are granulocytic immune that reside in tissues exposed to the external environment. MCs best known for their activity allergic reactions, but they have been involved different physiological and pathological conditions. In particular, MC infiltration has shown several types of human tumors animal cancer models. Nevertheless, role tumor microenvironment is still debated because associated either good or poor prognosis depending on type tissue localization. This dichotomous relies capacity secrete a broad spectrum molecules with modulatory functions, which may condition final outcome also promoting angiogenesis remodeling. this review, we analyze multifaceted mast cell progression inhibition considering ability interact with: i) cells, ii) iii) extracellular matrix. Eventually, current targeting strategies treat patients discussed. Deciphering actual onset crucial identify MC-targeted treatments aimed at killing making vulnerable selected anti-cancer drugs.

参考文章(97)
Laila Karra, Francesca Levi-Schaffer, Down-Regulation of Mast Cell Responses through ITIM Containing Inhibitory Receptors Advances in Experimental Medicine and Biology. ,vol. 716, pp. 143- 159 ,(2011) , 10.1007/978-1-4419-9533-9_9
CJ Meininger, H Yano, R Rottapel, A Bernstein, KM Zsebo, BR Zetter, The c-kit receptor ligand functions as a mast cell chemoattractant. Blood. ,vol. 79, pp. 958- 963 ,(1992) , 10.1182/BLOOD.V79.4.958.958
Lisa M. Coussens, Steven D. Shapiro, Paul D. Soloway, Zena Werb, Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice. Methods of Molecular Biology. ,vol. 151, pp. 149- 179 ,(2001) , 10.1385/1-59259-046-2:149
Vanina A. Medina, Elena S. Rivera, Histamine receptors and cancer pharmacology British Journal of Pharmacology. ,vol. 161, pp. 755- 767 ,(2010) , 10.1111/J.1476-5381.2010.00961.X
Raja M. Abdel-Majid, Jean S. Marshall, Prostaglandin E2 Induces Degranulation-Independent Production of Vascular Endothelial Growth Factor by Human Mast Cells Journal of Immunology. ,vol. 172, pp. 1227- 1236 ,(2004) , 10.4049/JIMMUNOL.172.2.1227
Mindy Tsai, Michele Grimbaldeston, Stephen J. Galli, Mast Cells and Immunoregulation/Immunomodulation Advances in Experimental Medicine and Biology. ,vol. 716, pp. 186- 211 ,(2011) , 10.1007/978-1-4419-9533-9_11
Susanna Mandruzzato, Samantha Solito, Erika Falisi, Samuela Francescato, Vanna Chiarion-Sileni, Simone Mocellin, Antonio Zanon, Carlo R. Rossi, Donato Nitti, Vincenzo Bronte, Paola Zanovello, IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients Journal of Immunology. ,vol. 182, pp. 6562- 6568 ,(2009) , 10.4049/JIMMUNOL.0803831
Vivianne Malmström, Deborah Shipton, Baljit Singh, Aymen Al-Shamkhani, Michael J. Puklavec, A. Neil Barclay, Fiona Powrie, CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice The Journal of Immunology. ,vol. 166, pp. 6972- 6981 ,(2001) , 10.4049/JIMMUNOL.166.11.6972
Ilia J. Elenkov, George P. Chrousos, Ronald L. Wilder, Thomas A. Fleisher, Dimitris A. Papanicolaou, Elizabeth Webster, Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors Journal of Immunology. ,vol. 161, pp. 2586- 2593 ,(1998)
Ross K. Morgan, Brian McAllister, Lillian Cross, Daniel S. Green, Hardy Kornfeld, David M. Center, William W. Cruikshank, Histamine 4 Receptor Activation Induces Recruitment of FoxP3+ T Cells and Inhibits Allergic Asthma in a Murine Model Journal of Immunology. ,vol. 178, pp. 8081- 8089 ,(2007) , 10.4049/JIMMUNOL.178.12.8081