作者: A. Rigoni , M. P. Colombo , C. Pucillo
DOI: 10.1007/S12307-014-0152-8
关键词:
摘要: Mast cells (MCs) are granulocytic immune that reside in tissues exposed to the external environment. MCs best known for their activity allergic reactions, but they have been involved different physiological and pathological conditions. In particular, MC infiltration has shown several types of human tumors animal cancer models. Nevertheless, role tumor microenvironment is still debated because associated either good or poor prognosis depending on type tissue localization. This dichotomous relies capacity secrete a broad spectrum molecules with modulatory functions, which may condition final outcome also promoting angiogenesis remodeling. this review, we analyze multifaceted mast cell progression inhibition considering ability interact with: i) cells, ii) iii) extracellular matrix. Eventually, current targeting strategies treat patients discussed. Deciphering actual onset crucial identify MC-targeted treatments aimed at killing making vulnerable selected anti-cancer drugs.