Cytochrome P450 in Humans
作者： F. J. Gonzalez
DOI: 10.1007/978-3-642-77763-9_16
关键词: Isozyme 、 Metabolic pathway 、 Human cytochrome 、 Biochemistry 、 Cytochrome P450 、 CYP2D6 Gene 、 Genetics 、 Steroid synthesis 、 Xenobiotic 、 Biology 、 Catabolism
摘要: This chapter will focus on the catabolic or foreign compound (xenobiotic)- metabolizing cytochromes P450 found in humans. Those involved metabolic pathways leading to steroid synthesis be thoroughly dealt with other chapters of handbook.
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RR Meehan, JR Gosden, Rout D, ND Hastie, T Friedberg, M Adesnik, R Buckland, V Van Heyningen, J Fletcher, NK Spurr, J Sweeney, CR Wolf, Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10. American Journal of Human Genetics. ,vol. 42, pp. 26- 37 ,(1988)
O. W Mcbride, A. K Jaiswal, F. J Gonzalez, D. W Nebert, Human P3450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15 Experimental pathology. ,vol. 3, pp. 1- 17 ,(1987)
D W Nebert, O W McBride, K Ikeya, D D Petersen, A E Bale, H H Smith, C E McKinney, Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. American Journal of Human Genetics. ,vol. 48, pp. 720- 725 ,(1991)
S T Okino, L C Quattrochi, U R Pendurthi, O W McBride, R H Tukey, Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing. Journal of Biological Chemistry. ,vol. 262, pp. 16072- 16079 ,(1987) , 10.1016/S0021-9258(18)47697-1
Dominique Diaz, Isabelle Fabrev, Martine Daujat, Bernard Saint Aubert, Philippe Bories, Henri Michel, Patrick Maurel, Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450 Gastroenterology. ,vol. 99, pp. 737- 747 ,(1990) , 10.1016/0016-5085(90)90963-2
P J Scambler, M Farrall, J R Idle, F J Gonzalez, O W McBride, Colin Dolphin, B A Brooks, The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1. American Journal of Human Genetics. ,vol. 43, pp. 280- 284 ,(1988)
B J Song, H V Gelboin, S S Park, C S Yang, F J Gonzalez, Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. Journal of Biological Chemistry. ,vol. 261, pp. 16689- 16697 ,(1986) , 10.1016/S0021-9258(18)66620-7
M Umeno, B J Song, C Kozak, H V Gelboin, F J Gonzalez, The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. Journal of Biological Chemistry. ,vol. 263, pp. 4956- 4962 ,(1988) , 10.1016/S0021-9258(18)68880-5
F P Guengerich, M V Martin, P H Beaune, P Kremers, T Wolff, D J Waxman, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry. ,vol. 261, pp. 5051- 5060 ,(1986) , 10.1016/S0021-9258(19)89213-X
T Aoyama, S Yamano, D J Waxman, D P Lapenson, U A Meyer, V Fischer, R Tyndale, T Inaba, W Kalow, H V Gelboin, F J Gonzalez, Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. Journal of Biological Chemistry. ,vol. 264, pp. 10388- 10395 ,(1989) , 10.1016/S0021-9258(18)81632-5