Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis.
作者： Naoki Maruyama , Akihito Ishigami , Setsuko Handa , Yong-Sun Kim , Eun-Kyoung Choi
DOI: 10.1007/S10165-012-0748-0
关键词: Immunology 、 Arthritis 、 Medicine 、 Monoclonal 、 Rheumatoid arthritis 、 Rheumatology 、 Autoantibody 、 Antibody 、 Pathogenesis 、 Internal medicine 、 Protein-Arginine Deiminase Type-4
摘要: Objective The peptidylarginine deiminase 4 (PAD4) gene and PAD4 autoantibodies have been associated with rheumatoid arthritis (RA) its pathogenesis. Therefore, methods for accurately determining their levels in the peripheral blood of these patients would be a diagnostic asset. The objective our study was to adapt enzyme-linked immunosorbent assay (ELISA) method evaluating human blood.
springer.com
sci-hub.se 参考文章(34)
Frank C Arnett, None, Revised criteria for the classification of rheumatoid arthritis. Bulletin on The Rheumatic Diseases. ,vol. 38, pp. 1- 6 ,(1989)
Akihito Ishigami, Naoki Maruyama, Importance of research on peptidylarginine deiminase and citrullinated proteins in age‐related disease Geriatrics & Gerontology International. ,vol. 10, ,(2010) , 10.1111/J.1447-0594.2010.00593.X
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Byungki Jang, Eunah Kim, Jin-Kyu Choi, Jae-Kwang Jin, Jae-Il Kim, Akihito Ishigami, Naoki Maruyama, Richard I. Carp, Yong-Sun Kim, Eun-Kyoung Choi, Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. American Journal of Pathology. ,vol. 173, pp. 1129- 1142 ,(2008) , 10.2353/AJPATH.2008.080388
Y. Takizawa, T. Sawada, A. Suzuki, R. Yamada, T. Inoue, K. Yamamoto, Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis. Scandinavian Journal of Rheumatology. ,vol. 34, pp. 212- 215 ,(2005) , 10.1080/03009740510026346-1
AKIHITO ISHIGAMI, HIROAKI ASAGA, TAKAKO OHSAWA, KYOICHI AKIYAMA, NAOKI MARUYAMA, Peptidylarginine deiminase type I, type II, type III and type IV are expressed in rat epidermis Biomedical Research-tokyo. ,vol. 22, pp. 63- 65 ,(2001) , 10.2220/BIOMEDRES.22.63
Kazutada Watanabe, Kyoichi Akiyama, Kiyoko Hikichi, Rika Ohtsuka, Ayumi Okuyama, Tatsuo Senshu, Combined biochemical and immunochemical comparison of peptidylarginine deiminases present in various tissues Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 966, pp. 375- 383 ,(1988) , 10.1016/0304-4165(88)90088-8
Münevver Serdaroğlu, Haşim Çakırbay, Orhan Değer, Sevil Cengiz, Sibel Kul, The association of anti-CCP antibodies with disease activity in rheumatoid arthritis Rheumatology International. ,vol. 28, pp. 965- 970 ,(2008) , 10.1007/S00296-008-0570-3
Erik R. Vossenaar, Albert J.W. Zendman, Walther J. van Venrooij, Ger J.M. Pruijn, PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. BioEssays. ,vol. 25, pp. 1106- 1118 ,(2003) , 10.1002/BIES.10357
Anthony P. Nicholas, Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience Letters. ,vol. 495, pp. 26- 29 ,(2011) , 10.1016/J.NEULET.2011.03.028