Glass-like dynamics in the cell and in cellular collectives.

摘要: Prominent fluctuations, heterogeneity, and cooperativity dominate the dynamics of cytoskeleton as well cellular collective. Such systems are out equilibrium, disordered, remain poorly understood. To explain these findings, we consider a unifying mechanistic rubric that imagines comprising phases soft condensed matter in proximity to glass or jamming transition, with associated transitions between solid-like versus liquid-like phases. At scale cytoskeleton, data suggest intermittent dynamics, kinetic arrest, dynamic heterogeneity represent mesoscale features glassy protein-protein interactions link underlying biochemical events integrative behaviors such crawling, contraction, remodeling. multicellular collective, has potential unify diverse biological factors previously had been considered mostly acting separately independently. Although quantitative relationship intra- intercellular is still lacking, offer insights linking mechanobiology cell human physiology pathophysiology.