The EORTC randomized trial on three fractions per day and misonidazole in advanced head and neck cancer: prognostic factors
作者： Walter Van den Bogaert , Emmanuel van der Schueren , Jean Claude Horiot , Mario De Vilhena , Simon Schraub
DOI: 10.1016/0167-8140(95)01539-S
关键词: Survival rate 、 Oncology 、 Misonidazole 、 Performance status 、 Surgery 、 Clinical trial 、 Internal medicine 、 Medicine 、 Univariate analysis 、 Head and neck cancer 、 Randomized controlled trial 、 Radiosensitizer
摘要: In trial no. 22811 on a randomized comparison of multiple fractions per day (MFD), with or without misonidazole, to conventional fractionation in advanced head and neck cancer, large number (523) patients was entered short period time. No differences treatment results were obtained, but the study created an important database, allowing for detailed evaluation most factors influencing prognosis. univariate analysis, significantly survival locoregional control were: performance status, histological differentiation, tumor site, nodal staging, tumoral volume. multivariate significant involvement, stage, site. Significant involvement total burden. This analysis suggests that burden (volume) should be included interpretation cancer.
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