Pulmonary embolism on postmortem examination: an under-recognized complication in lung-transplant recipients?

作者: Karen E. A. Burns , Aldo T. Iacono

DOI: 10.1097/01.TP.0000114308.94880.2A

关键词: Cause of deathSurgeryBronchiolitis obliteransPulmonary embolismTransplantationBacterial pneumoniaLung transplantationAutopsyInternal medicineMedicineRespiratory disease

摘要: Introduction. Postmortem reports highlight the importance of factors that individually or collectively limit survival. The prevalence pulmonary embolism (PE) at autopsy in lung-transplant recipients has not been characterized previously. Objective. We aimed to describe PE, infection, and acute chronic rejection their respective contributions death according survival posttransplantation. Methods. retrospectively reviewed 126 performed lung-and heart–lung-transplant between June 1990 September 2002. Results. PE was identified 34 (27.0%) lung- recipients. autopsy-established highest, 36.4%, early group (1–30 days) compared with 20.0% 23.8% intermediate (31–365 late (>365 groups, respectively. Although fungal viral pneumonia were noted most frequently bacterial 32% 45% autopsies over posttransplant period. Acute cellular bronchiolitis obliterans present 29.5% 2.3%, 40.0% 17.5%, 35.7% 42.9% patients early, intermediate, frequent cause infection. Conclusions. highest mechanically ventilated postoperative Heart-lung lower risk for double- single-lung may be an under-appreciated complication contributing respiratory failure

参考文章(14)
T Winton, A De Hoyos, D Chamberlain, J R Maurer, C Chaparro, G Westney, S Kesten, Causes of death in lung transplant recipients. Journal of Heart and Lung Transplantation. ,vol. 13, pp. 758- 766 ,(1994)
S. A. Yousem, G. J. Berry, J. Ritter, D. Chamberlain, N. P. Ohori, H. D. Tazelaar, A. Marchevsky, Philip T. Cagle, A. N. Husain, S. Stewart, R. H. Hruban, Revision of the 1990 working formulation for the classification of pulmonary allograft rejection : Lung Rejection Study Group Journal of Heart and Lung Transplantation. ,vol. 15, pp. 1- 15 ,(1996)
Vijay Yeldandi, Momin T. Siddiqui, Alvaro Montoya, Vijaya B. Reddy, Edward R. Garrity, Aliya N. Husain, Postmortem findings in lung transplant recipients. Modern Pathology. ,vol. 9, pp. 752- 761 ,(1996)
A. L. Gut, A. L. A. Ferreira, M. R. Montenegro, Autopsy: quality assurance in the ICU. Intensive Care Medicine. ,vol. 25, pp. 360- 363 ,(1999) , 10.1007/S001340050858
Henry D. Tazelaar, Samuel A. Yousem, The pathology of combined heart-lung transplantation: An autopsy study Human Pathology. ,vol. 19, pp. 1403- 1416 ,(1988) , 10.1016/S0046-8177(88)80233-8
William C. Roberts, The Autopsy: Its Decline and a Suggestion for Its Revival The New England Journal of Medicine. ,vol. 299, pp. 332- 338 ,(1978) , 10.1056/NEJM197808172990704
Hatsue Ishibashi-Ueda, Guy Chomette, Annick Delcourt, Michelle Auriol, Yves Le Charpentier, Christian Cabrol, A pathologic analysis of the outcome following heart-lung transplantation: an autopsy study of 22 recipients. Heart and Vessels. ,vol. 6, pp. 211- 217 ,(1991) , 10.1007/BF02125099
PILAR FERNANDEZ-SEGOVIANO, AURORA LÁZARO, ANDRES ESTEBAN, JOSE MANUEL RUBIO, JOSE R. IRURETAGOYENA, Autopsy as quality assurance in the intensive care unit Critical Care Medicine. ,vol. 16, pp. 683- 685 ,(1988) , 10.1097/00003246-198807000-00007
Timothy J. Kroshus, Vibhu R. Kshettry, Marshall I. Hertz, R.Morton Bolman, Deep venous thrombosis and pulmonary embolism after lung transplantation The Journal of Thoracic and Cardiovascular Surgery. ,vol. 110, pp. 540- 544 ,(1995) , 10.1016/S0022-5223(95)70252-0