Analgesic electrical stimulation of the hypothalamic arcuate nucleus: tolerance and its cross-tolerance to 2 Hz or 100 Hz electroacupuncture
作者： Qiang Wang , Limin Mao , Jisheng Han
DOI: 10.1016/0006-8993(90)90951-7
关键词: Analgesic 、 Tail flick latency 、 Anesthesia 、 Hypothalamus 、 Pentobarbital 、 Stimulation 、 Endocrinology 、 Electroacupuncture 、 Cross-tolerance 、 Arcuate nucleus 、 Internal medicine 、 Medicine
摘要: Focal electrical stimulation of the arcuate nucleus hypothalamus (ARH) for 5 min (1 session) produced a marked elevation tail flick latency (TFL) to noxious heat in pentobarbital-anesthetized rat. Repeated total 11 sessions at 30 intervals resulted gradual decline hypoalgesic action, and this tolerance may last 7 days. Tolerance ARH analgesic reduced analgesia by low (2 Hz) but not high (100 frequency electroacupuncture (EA); EA attenuated stimulation-produced without affecting analgesia. Alternatively, rats tolerant high-frequency were still sensitive either or low-frequency stimulation. These results suggest that administration via common neural mechanism, supporting our hypothesis put forward previously plays an important role mediating low-
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