Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis -Acting Elements ERSE, UPRE and ERSE-II

摘要: ATF6 and XBP1 are transcription factors activated specifically in response to endoplasmic reticulum (ER) stress. Three cis-acting elements capable of binding ATF6, or both have been identified date, namely ER stress-response element (ERSE), unfolded protein (UPRE) ERSE-II. ERSE controls the expression ER-localized molecular chaperones such as BiP that can refold proteins ER; from is fully by even absence XBP1. In contrast, UPRE depends solely on it has suggested may control components ER-associated degradation system degrade ER. The Herp gene, one most highly inducible genes under stress, encodes an membrane containing a ubiquitin-like domain with unknown functions, carries ERSE-II addition its promoter. this report, we show allows NF-Y-dependent case NF-Y-independent UPRE, mitigated Accordingly, induction mRNA was diminished whereas not affected. These results help understanding role quality