Cortical Signature of Neurological Soft Signs in Recent Onset Schizophrenia
作者： Dusan Hirjak , Robert Christian Wolf , Bram Stieltjes , Thomas Hauser , Ulrich Seidl
DOI: 10.1007/S10548-013-0292-Z
关键词: Psychology 、 Neurology 、 Magnetic resonance imaging 、 Inferior parietal lobule 、 Temporal lobe 、 Neuroscience 、 Neuroimaging 、 Schizophrenia 、 Precuneus 、 Gyrus
摘要: Motor symptoms such as neurological soft signs (NSS) are characteristic phenomena of schizophrenia at any stage the illness. Neuroimaging studies in patients have shown regional thinning cortical mantle, but it is unknown present whether NSS related to thickness changes. Whole brain high-resolution magnetic resonance imaging 3 Tesla was used investigate 28 with recent-onset schizophrenia. Cortical reconstruction performed Freesurfer image analysis suite. were examined on Heidelberg Scale and thickness. Age, education, medication considered potential confounders. Higher scores associated morphological changes multiple areas comprising paracentral gyrus, postcentral lobule, precuneus, inferior parietal lobule temporal lobe. Our results confirm hypothesis a significant relationship between extent Investigation may help explain subtle motor
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Li Kong, Christina Herold, Bram Stieltjes, Marco Essig, Ulrich Seidl, Robert Christian Wolf, Torsten Wüstenberg, Marc Montgomery Lässer, Lena Anna Schmid, Knut Schnell, Dusan Hirjak, Philipp Arthur Thomann, Reduced gray to white matter tissue intensity contrast in schizophrenia. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0037016
Wei Wen, Yong He, Perminder Sachdev, Structural brain networks and neuropsychiatric disorders. Current Opinion in Psychiatry. ,vol. 24, pp. 219- 225 ,(2011) , 10.1097/YCO.0B013E32834591F8
Zi-wen Peng, Ting Xu, Guo-dong Miao, Qing-huan He, Qing Zhao, Paola Dazzan, Raymond C.K. Chan, Neurological soft signs in obsessive–compulsive disorder: The effect of co-morbid psychosis and evidence for familiality Progress in Neuro-Psychopharmacology and Biological Psychiatry. ,vol. 39, pp. 200- 205 ,(2012) , 10.1016/J.PNPBP.2012.06.015
Simone Kühn, Christian Kaufmann, Daniela Simon, Tanja Endrass, Jürgen Gallinat, Norbert Kathmann, Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. Cortex. ,vol. 49, pp. 2178- 2185 ,(2013) , 10.1016/J.CORTEX.2012.09.001
Vincent Corbo, Marie-Hélène Clément, Jorge L. Armony, Jens C. Pruessner, Alain Brunet, Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biological Psychiatry. ,vol. 58, pp. 119- 124 ,(2005) , 10.1016/J.BIOPSYCH.2005.02.032
Aaron L. Goldman, Lukas Pezawas, Venkata S. Mattay, Bruce Fischl, Beth A. Verchinski, Qiang Chen, Daniel R. Weinberger, Andreas Meyer-Lindenberg, Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of Heritability Archives of General Psychiatry. ,vol. 66, pp. 467- 477 ,(2009) , 10.1001/ARCHGENPSYCHIATRY.2009.24
Johannes Schröder, Marco Essig, Klaus Baudendistel, Thomas Jahn, Ingo Gerdsen, Andreas Stockert, Lothar R. Schad, Michael V. Knopp, Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: A study with functional magnetic resonance imaging. NeuroImage. ,vol. 9, pp. 81- 87 ,(1999) , 10.1006/NIMG.1998.0387
D. S. Bassett, E. Bullmore, B. A. Verchinski, V. S. Mattay, D. R. Weinberger, A. Meyer-Lindenberg, Hierarchical Organization of Human Cortical Networks in Health and Schizophrenia The Journal of Neuroscience. ,vol. 28, pp. 9239- 9248 ,(2008) , 10.1523/JNEUROSCI.1929-08.2008
Moo K. Chung, Keith J. Worsley, Steve Robbins, Tomáš Paus, Jonathan Taylor, Jay N. Giedd, Judith L. Rapoport, Alan C. Evans, Deformation-based surface morphometry applied to gray matter deformation. NeuroImage. ,vol. 18, pp. 198- 213 ,(2003) , 10.1016/S1053-8119(02)00017-4
Bayanne Olabi, Ian Ellison-Wright, Andrew M. McIntosh, Stephen J. Wood, Ed Bullmore, Stephen M. Lawrie, Are There Progressive Brain Changes in Schizophrenia? A Meta-Analysis of Structural Magnetic Resonance Imaging Studies Biological Psychiatry. ,vol. 70, pp. 88- 96 ,(2011) , 10.1016/J.BIOPSYCH.2011.01.032