Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: A study with functional magnetic resonance imaging.

摘要: Recent studies demonstrate a diminished activation of the sensorimotor cortex and supplementary motor area (SMA) in schizophrenia which may be involved pathogenesis neurological soft signs (NSS). Yet, question whether retarded performance account for these changes remained to clarified. Twelve DSM-III-R schizophrenics 12 healthy controls were included. All subjects right-handed. Nine patients received clozapine, two conventional neuroleptics, one was drug-free. Functional magnetic resonance imaging (fMRI) obtained resting condition during pronation/supination at three speed levels (low, medium, high) with recorded simultaneously using device. While measures retardation (i.e., repetition rate amplitude movements) did not differ between controls, variability significantly (P < 0.05) increased patients' group. In addition, showed decreased cortices. Similar, although nonsignificant = 0.09) observed SMA. Activation differences more pronounced slow drug-free patient. These results confirm SMA indicate that rather than per se correspond changes.