25-hydroxydihydrotachysterol2 an innovative synthesis of a key metabolite of dihydrotachysterol2
作者： Jaap C. Hanekamp , Rob Boer Rookhuizen , Hendrik J.T. Bos , Lambert Brandsma
DOI: 10.1016/S0040-4020(01)85618-0
关键词: Synthon 、 Total synthesis 、 Bicyclic molecule 、 Organic chemistry 、 Steroid 、 Aliphatic compound 、 Wittig reaction 、 Metabolite 、 Chemistry
摘要: Abstract A new synthesis of 25-hydroxydihydrotachysterol 2 is described. The hydroxylated side-chain constructed stereoselectively using a chiral Wittig reagent. A-ring synthon introduced utilising the Wittig-Horner method as developed by Lithgoe et al. preparation metabolite carried out in 18 steps.
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