Structural analogues of vitamin D
作者： Pierre Jean de Clercq , Maurits Vandewalle , Roger Bouillon
DOI:
关键词: Metabolite 、 Vitamin D and neurology 、 Vitamin D Analogue 、 Chemistry 、 Stereochemistry 、 Moiety
摘要: The present invention relates to analogues of vitamin D, which lack the combined presence trans-fused six-membered C-ring and five-membered D-ring, but still possess a central part consisting substituted chain five atoms, atoms correspond positions 8, 14, 13, 17 20 at ends are connected, position structural moiety representing side-chain D or an analogue 8 Δ(5,7)-diene connected A-ring active 1-alpha-hydroxy metabolite established analogue, their preparation process, intermediates, pharmaceutical preparations comprising these compounds use in medicine.
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