Immunoglobulin G4-related disease mimicking lymphoma in a Chinese patient.

摘要: Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by multiorgan fibrosis with IgG4-producing plasma cells, increased IgG4 serum concentration, and responsiveness to steroid therapy. IgG4-RD tends form tumefactive lesions. As result, patients are often suspected of having malignancy such as lymphoma. In this article, patient the deep vein thrombosis who was initially lymphoma reported. The 63-year-old man presented painless salivary swelling multi-lymphadenopathy, progressively pain in left leg. Salivary biopsy showed IgG4+ cells >50 per high-power field IgG4+/IgG+ cell ratio >40 %. level 4.28 g/L (range 0.03–2.01 mg/dL). Ultrasonography that inferior vena cava partially occluded, iliac vein. Computed tomography scan revealed plaque-like tissue surrounding abdominal aortic, which typical for diagnosis retroperitoneal fibrosis. effectively treated corticosteroids, interventional therapy, anticoagulant therapy resulted reduction lymph nodes Patient rare could be misdiagnosed easily malignant disease. Accurate critical management.