Intra arterial chemotherapy with ACNU and radiotherapy in inoperable malignant gliomas.
作者： L. Chauveinc , M.T. Sola-Martinez , M. Martin-Duverneuil , J.J. Mazeron , T. Faillot
DOI: 10.1007/BF00177477
关键词: Central nervous system disease 、 Glioma 、 Radiation therapy 、 Surgery 、 Toxicity 、 Chemotherapy 、 Visual acuity 、 Medicine 、 Survival rate 、 Anaplastic astrocytoma
摘要: For the non-operable malignant glioma patients, prognosis remains poor, with a survival of 8 months for glioblastomas (G), and 15 anaplastic astrocytomas (AA). 27 histologic proven gliomas (17 AA 10 G) were treated between April 1991 June 1992. Median age was 48 years. The therapeutic protocol consisted three courses intra arterial chemotherapy (IAC) ACNU, at intervals six weeks, localised 60 Gy radiotherapy first second IAC course. 72 delivered (2,4 per patient). Response rate 51,8%. (MS) 13 months, 28% 24 months. AA, MS 21 37% G, median Responders 65 % 30% G. Non responders all died before had relapsed 9 54% responding patients 2 years survival. Toxicity acceptable 7% haematological toxicity partial loss visual acuity in 11% cases. No chronic neurological sequellae noted. We compare theses results two previous trials, concerning inoperable by an association systemic chemotherapy. Survival seems to be equivalent HeCNU this treatment, but decreases ACNU. Early does not increase complications. This treatment can used gliomas.
springer.com
sci-hub.se 参考文章(22)
Gutin Ph, Wara Wm, Nutik S, Davis Rl, Yatsko K, Silver P, Wilson Cb, Resser Kj, Levin Va, Northern California Oncology Group protocol 6G91: response to treatment with radiation therapy and seven-drug chemotherapy in patients with glioblastoma multiforme. Cancer treatment reports. ,vol. 70, pp. 739- 743 ,(1986)
A. Ameri, M. Poisson, L. Chauveinc, Q.M. Chen, JY Delattre, Treatment of recurrent malignant supratentorial gliomas with the association of carboplatin and etoposide: a phase II study. Journal of Neuro-oncology. ,vol. 32, pp. 155- 160 ,(1997) , 10.1023/A:1005784425680
MarcK. Rosenblum, Jean-Yves Delattre, RussellW. Walker, WilliamR. Shapiro, Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: a pathological study. Journal of Neuro-oncology. ,vol. 7, pp. 269- 281 ,(1989) , 10.1007/BF00172921
Norbert Roosen, Jürgen C. W. Kiwit, Evaldo Lins, Michael Schirmer, Wolfgang J. Bock, Adjuvant intraarterial chemotherapy with nimustine in the management of world health organization grade IV gliomas of the brain. Experience at the department of neurosurgery of Düsseldorf university Cancer. ,vol. 64, pp. 1984- 1994 ,(1989) , 10.1002/1097-0142(19891115)64:10<1984::AID-CNCR2820641003>3.0.CO;2-S
Junkoh Yamashita, Hajime Handa, Yasuhiko Tokuriki, Young Soo Ha, Shin-Ichi Otsuka, Kinya Suda, Waro Taki, Intra-arterial ACNU therapy for malignant brain tumors: Experimental studies and preliminary clinical results Journal of Neurosurgery. ,vol. 59, pp. 424- 430 ,(1983) , 10.3171/JNS.1983.59.3.0424
SP Stenning, LS Freedman, NM Bleehen, An overview of published results from randomized studies of nitrosoureas in primary high grade malignant glioma British Journal of Cancer. ,vol. 56, pp. 89- 90 ,(1987) , 10.1038/BJC.1987.161
Felipe Vega, Luis Davila, Gilles Chatellier, Jacques Chiras, Fran�ois Fauchon, Philippe Cornu, Laurent Capelle, Michel Poisson, JeanYves Delattre, Treatment of malignant gliomas with surgery, intraarterial chemotherapy with ACNU and radiation therapy Journal of Neuro-oncology. ,vol. 13, pp. 131- 135 ,(1992) , 10.1007/BF00172762
Luis A. Rodriguez, Michael Prados, Pamela Silver, Victor A. Levin, Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors Cancer. ,vol. 64, pp. 2420- 2423 ,(1989) , 10.1002/1097-0142(19891215)64:12<2420::AID-CNCR2820641204>3.0.CO;2-B
Pierre Pouillart, Georges Mathe, Thao Hoang Thy, Jean Lheritier, Maurice Poisson, Pierre Huguenin, Henry Gauthier, Philippe Morin, Robert Parrot, Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU.Results of a phase II trial Cancer. ,vol. 38, pp. 1909- 1916 ,(1976) , 10.1002/1097-0142(197611)38:5<1909::AID-CNCR2820380507>3.0.CO;2-Q
M. Contin, R. Riva, P. Martinelli, P. Cortelli, F. Albani, A. Baruzzi, Pharmacodynamic modeling of oral levodopa: Clinical application in Parkinson's disease Neurology. ,vol. 43, pp. 367- 367 ,(1993) , 10.1212/WNL.43.2.367