Long-term follow-up of liver transplanted HIV/hepatitis B virus coinfected patients: perfect control of hepatitis B virus replication and absence of mitochondrial toxicity.

摘要: BACKGROUND In patients coinfected with hepatitis B virus (HBV) and human immunodeficiency (HIV), evolution toward cirrhosis its complications is more rapid severe than in infected HBV alone. The outcome of liver transplantation HBV-HIV-coinfected poorly understood terms survival rate, reactivation mitochondrial toxicity on the graft. PATIENTS AND METHODS Between November 2002 June 2007, 13 HIV-positive underwent because end-stage disease due to or without coinfection D C virus. These were prospectively followed for an average 32 +/- 5.2 months (range 10-63 months). RESULTS All alive at end follow-up period had normal function. Their viral load was undetectable, no cccDNA found graft HIV infection nonprogressive under antiretroviral therapy. Moreover, noted graft, as assessed by spectrophotometric analysis respiratory chain activities quantifying DNA copy number. CONCLUSION can successfully undergo excellent results survival, control replication after toxicity.