Late-onset cytomegalovirus disease in patients with solid organ transplant.

作者: Pascal R Meylan , Oriol Manuel

DOI: 10.1097/QCO.0B013E328236742E

关键词: ImmunityLate onsetTransplantationDiscontinuationImmune systemCytomegalovirus diseaseMedicineIntensive care medicineCongenital cytomegalovirus infectionDisease

摘要: PURPOSE OF REVIEW To review existing data regarding late cytomegalovirus disease occurring after antiviral prophylaxis. RECENT FINDINGS There is a continued debate as to the respective merits of preemptive and prophylactic approach prevent transplantation. Arguably, by allowing some infection, helps build immunity in contrast prophylaxis, explaining occurrence latter approach. No study comparing directly both approaches large enough definitely determine whether leads faster development immune response protective from nor clinically different prophylaxis compared early diseases. While risk factors for all point delay mounting responses, there are no identified markers that would help predict at time discontinuation. Various have been developed: prolonged microbiological surveillance treatment Considering identifying disease, it also make sense envision vaccinating cytomegalovirus-seronegative recipients. SUMMARY The best or manage associated with remains be defined.

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