QuantiFERON®-CMV assay for the assessment of cytomegalovirus cell-mediated immunity
作者： Stefano Giulieri , Oriol Manuel
DOI: 10.1586/ERM.10.109
关键词: QuantiFERON 、 Cellular immunity 、 Disease 、 Congenital cytomegalovirus infection 、 Incidence (epidemiology) 、 Virology 、 Antigen 、 Immunology 、 Biology 、 Immunity 、 Cell mediated immunity 、 Pathology and Forensic Medicine 、 Molecular medicine 、 Genetics 、 Molecular biology
摘要: Cytomegalovirus (CMV) infection has historically been a major complication among immunocompromised patients, such as solid-organ and stem-cell transplant recipients patients with advanced HIV infection. While the introduction of antiretroviral therapy almost eradicated CMV in HIV-infected disease remains significant problem once antiviral prophylaxis is discontinued. QuantiFERON®-CMV allows assessment cellular immunity against by detecting production IFN-γ following vitro stimulation antigens. Preliminary studies have shown correlation between lack detectable cell-mediated measured QuantiFERON-CMV assay higher incidence patients. Measurement appears to be promising strategy identify at highest risk for development and, therefore, individualize preventive strategies fo...
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