Depression of benzodiazepine binding and diazepam potentiation of GABA-mediated inhibition after chronic exposure of spinal cord cultures to diazepam
作者： Phyllis K. Sher , Robert E. Study , Joann Mazzetta , Jeffery L. Barker , Phillip G. Nelson
DOI: 10.1016/0006-8993(83)90404-3
关键词: Benzodiazepine receptor binding 、 Diazepam 、 gamma-Aminobutyric acid 、 Benzodiazepine 、 Chemistry 、 Diazepam binding 、 Pharmacology 、 Spinal cord 、 Long-term potentiation 、 Inhibitory postsynaptic potential
摘要: Cultures of fetal mouse spinal cord were exposed to 12.6 microM (3.6 micrograms/ml) diazepam for 7 days. After drug removal, benzodiazepine receptor binding was assayed on intact cells and intracellular recordings effects GABA-mediated inhibitory responses obtained. The biochemical electrophysiological data revealed significant parallel reductions in both pharmacological action GABA which did not return control levels until 3-4 days after removal diazepam. results indicate that chronic exposure cultures a reversible down-regulation function.
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