Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.
作者： Bonnie Reinhart , Lucia Mazzacurati , Adriana Forero , Chang-Sook Hong , Junichi Eguchi
DOI: 10.1155/2012/815465
关键词: Lytic cycle 、 Virus 、 Herpes simplex virus 、 Viral replication 、 Biology 、 Virology 、 Indoleamine 2,3-dioxygenase 、 Innate immune system 、 Vector (molecular biology) 、 Oncolytic virus
摘要: Successful oncolytic virus treatment of malignant glioblastoma multiforme depends on widespread tumor-specific lytic replication and escape from mitigating innate immune responses to infection. Here we characterize a new HSV vector, JD0G, that is deleted for ICP0 the joint sequences separating unique long short elements viral genome. We observed JD0G was enhanced in certain cell lines compared HEL cells, suggesting vector backbone may be useful glioblastoma. The response infection can potentially impede human tumors. Indoleamine-2,3-dioxygenase (IDO) expressed interferon γ (IFNγ) has been linked both antiviral functions tumor cells. IFNγ cells induced expression IDO this quelled by with wild-type viruses. role inhibiting connection protein surveillance suggest downregulation enhance activity vectors such as JD0G.
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