Activation of liver X receptor improves viability of adipose-derived mesenchymal stem cells to attenuate myocardial ischemia injury through TLR4/NF-κB and Keap-1/Nrf-2 signaling pathways.
作者： Yabin Wang , Chunhong Li , Kang Cheng , Ran Zhang , Kazim Narsinh
关键词: Mesenchymal stem cell 、 Liver X receptor 、 Basic fibroblast growth factor 、 Tumor necrosis factor alpha 、 Internal medicine 、 Agonist 、 Proinflammatory cytokine 、 Cell therapy 、 Growth factor 、 Endocrinology 、 Cancer research 、 Biology
摘要: Abstract Aims: Clinical application of cellular therapy for cardiac regeneration is significantly hampered by the low retention engrafted cells, mainly attributable to poor microenvironment dominated inflammation and oxidative stress in host's infarcted myocardium. This study aims at investigating whether liver X receptor (LXR) agonist T0901317 will improve survival adipose-derived mesenchymal stem cells (AD-MSCs) after transplantation into hearts. Results: Noninvasive vivo bioluminescence imaging histological staining showed that LXR improved intramyocardially injected AD-MSCs. Moreover, combined AD-MSCs inhibited host cardiomyocyte apoptosis, reduced fibrosis, function, while it concomitantly decreased inflammatory cytokines (e.g., tumor necrosis factor-α interleukin-6) increased growth factor vascular endothelial basic fibroblast factor...
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