Increased Extracellular Deposition of Fibrillin-Containing Fibrils in Pseudoexfoliation Syndrome

摘要: Purpose. To localize the distribution of fibrillin-containing microfibrils in normal human anterior segment tissues and to characterize role fibrillin pathogenesis pseudoexfoliation syndrome. Methods. Anterior were obtained from 10 eyes with syndrome investigated by indirect immunofluorescence electron microscopic immunogold labeling using a monoclonal antibody fibrillin-1. Results. In addition zonular fibers, fibrillin-immunoreactive microfibrillar bundles generally found corneal stroma; stromal connective conjunctiva, ciliary body, iris, especially iris root area; periphery Schlemm's canal, scleral spur, most portion trabecular meshwork; muscle, dilator sphincter muscles iris; basement membranes peripheral epithelium, conjunctival pigmented lens capsule. The be isolated or association elastic fibers cellular membranes. eyes, an additional strong immunoreaction was localized their subuniis close proximity surfaces cells involved fiber production. Conclusions. system ocular is suggested have substantial maintenance tissue integrity providing tensile strength flexibility mechanically strained tissues. findings further provide evidence for as intrinsic component suggesting possibility that enhanced expression abnormal aggregation may Invest Ophthalmol Vis Sci. 1997; 38:970-984.