Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes.
作者： Beatrice Y. J. T. Yue , Kelly Wentz-Hunter , Jun Ueda
DOI:
关键词: Laminin 、 Myocilin 、 Fibronectin 、 Fibrillin 、 Elastin 、 Immunoelectron microscopy 、 Pathology 、 Extracellular matrix 、 Decorin 、 Chemistry
摘要: RESULTS. Amorphous basement membrane-like materials in the JCT were confirmed to be made up chiefly of collagen type IV, laminin, and fibronectin. Elastin was localized central core sheath-derived plaques. Fibronectin, fibrillin-1, MAGP-1, decorin, VI all clusters banded material sheath surrounding core, where several types collagen, glycoproteins, proteoglycans also detected. Myocilin found associate mainly with material, overlapping extensively distribution fibronectin, MAGP-1 moderately decorin collagen. Its localization distinct from that elastin. Interactions myocilin molecules such as fibronectin fibrillin-1 biochemically. CONCLUSIONS. This study illustrated ultrastructurally composition ECM normal human eyes. The key finding association microfibrillar architecture plaques pathologic changes have been documented occur eyes patients primary open-angle glaucoma. (Invest Ophthalmol Vis Sci. 2002;43:1068 ‐1076)
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