Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing

摘要: Abstract Background Over the past years, plasma medicine has developed from an unknown and little accepted medical field into integral part of research subsequently clinical treatment. The cellular mechanisms mediated by treatment in wound healing are well investigated, sources specifically for treating disorders already available. Nevertheless, results obtained with one source cannot be simply transferred to another device. reason this non-transferability is biological effects caused ‘cocktail’ reactive species, radiation (above all ultraviolet light), electrical current flow body, working gas, heat transfer treated surface, depending on generation technology. Therefore, avoid toxic, mutagenic, or otherwise damaging effects, physical biomedical performance parameters each device need comprehensively evaluated before can used as a medicinal product. Objective This article compared most important molecular investigated vitro vivo context healing. Methods study two devices that CE-certified class IIa, kINPen®MED including experimental predecessor kINPen09 kINPen11 (summarized below under kINPen, jet, neoplas tools GmbH, Greifswald, Germany) MicroPlaSter/Adtec SteriPlas (plasma torch, Adtec Plasma Technology/Adtec Europe, Hiroshima, Japan/Hunslow, UK). Results kINPen MicroPlaSter both optically technically completely different devices. almost comparable regard their such collagen expression, induction healing-relevant cytokines growth factors, activation immune cells other protective mechanisms, improved differ effect cell proliferation migration, probably due times modalities action devices, cells. Conclusions comparative showed cold atmospheric several positive substantial, basic research.