Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial.

摘要: Background The development of antibiotic resistance by microorganisms is an increasing problem in medicine. In chronic wounds, bacterial colonization associated with impaired healing. Cold atmospheric plasma innovative promising tool to deal these problems. Objectives 5-min argon treatment has already demonstrated efficacy reducing numbers infected wounds vivo. this study we investigated a 2-min the same device and next-generation device, assess safety reduction load, regardless kind bacteria their level wounds. Methods Twenty-four patients were treated prospective randomized controlled phase II 2 min cold every day: 14 MicroPlaSter alpha 10 beta (next-generation device) addition standard wound care. patient acted as his ⁄her own control. Bacterial species detected swabs load semiquantitative count on nitrocellulose filters. settings previous which exposed for 5 plasma. Results Analysis 70 treatments revealed significant (40%, P <0 AE016) plasmatreated bacteria. 137 showed highly (23AE5%, AE008) load. No side-effects occurred was well tolerated. Conclusions A either two devices safe, painless effective technique decrease