Enantioselective Copper-Catalyzed Oxy-Alkynylation of Diazo Compounds

摘要: Enantioselective catalytic methods allowing the addition of both a nucleophile and an electrophile onto diazo compounds give fast access into important building blocks. Herein, we report highly enantioselective oxyalkynylation using ethynylbenziodoxol-(on)e reagents simple copper bisoxazoline catalyst. The obtained α-benzoyloxy propargylic esters are useful blocks, which difficult to synthesize in enantiopure form other methods. products could be efficiently transformed vicinal diols α-hydroxy without loss enantiopurity.