Primary Biliary Cirrhosis: Pathology
作者： Roderick N. M. MacSween
DOI: 10.1007/978-1-4684-7041-3_15
关键词: Primary sclerosing cholangitis 、 Jaundice 、 Bile duct 、 Pathology 、 Primary biliary cirrhosis 、 Disease 、 Medicine 、 Intrahepatic bile ducts 、 Cholestasis 、 Liver injury
摘要: The essential morphologic feature of primary biliary cirrhosis (PBC) comprises a chronic nonsuppurative destructive cholangitis.1 This is the lesion and results in progressive disappearing bile duct syndrome. Although there clinical and/or biochemical evidence cholestatic syndrome from time diagnosis, cholestasis does not appear until has been extensive loss intrahepatic ducts; jaundice with bilirubinostasis often still later poor prognostic import.2 In my view, progress liver injury PBC secondary to resulting ducts is, effect, cirrhosis. chapter describes features PBC, discusses some immunological aspects, speculates as pathogenetic mechanisms, poses unanswered questions relating this enigmatic disease.
springer.com
sci-hub.st 参考文章(41)
Fenton Schaffner, Hans Popper, Emanuel Rubin, PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. American Journal of Pathology. ,vol. 46, pp. 387- 407 ,(1965)
E L Reinherz, A K Bhan, J L Dienstag, J R Wands, S F Schlossman, Alterations of T-cell subsets in primary biliary cirrhosis. Clinical and Experimental Immunology. ,vol. 47, pp. 351- 358 ,(1982)
Peter J Scheuer, Primary biliary cirrhosis. Journal of the Royal Society of Medicine. ,vol. 60, pp. 1257- 1260 ,(1967) , 10.1177/003591576706001205
Dominique Bernuau, Gérard Feldmann, Claude Degott, Christian Gisselbrecht, Ultrastructural lesions of bile ducts in primary biliary cirrhosis: A comparison with the lesions observed in graft versus host disease Human Pathology. ,vol. 12, pp. 782- 793 ,(1981) , 10.1016/S0046-8177(81)80081-0
Yasuni Nakanuma, Goroku Ohta, Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis Gastroenterology. ,vol. 76, pp. 1326- 1332 ,(1979) , 10.1016/0016-5085(79)90396-2
Giuseppe Colucci, Massimo Colombo, Ersilio Del Ninno, Fiorenzo Paronetto, In Situ Characterization by Monoclonal Antibodies of the Mononuclear Cell Infiltrate in Chronic Active Hepatitis Gastroenterology. ,vol. 85, pp. 1138- 1145 ,(1983) , 10.1016/S0016-5085(83)80082-1
Roderick NM MacSween, Peter P Anthony, Peter J Scheuer, Alastair D Burt, Bernard C Portmann, Pathology of the liver : Churchill Livingstone. ,(1994)
Fenton Schaffner, Hans Popper, Progress in Liver Diseases ,(1982)
Bernard Portmann, Hans Popper, James Neuberger, Roger Williams, Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients Gastroenterology. ,vol. 88, pp. 1777- 1790 ,(1985) , 10.1016/0016-5085(85)90001-0
G.R. Pape, E.P. Rieber, J. Eisenburg, R. Hoffmann, C.M. Balch, G. Paumgartner, G. Riethmüller, Involvement of the cytotoxic/suppressor T-cell subset in liver tissue injury of patients with acute and chronic liver diseases Gastroenterology. ,vol. 85, pp. 657- 662 ,(1983) , 10.1016/0016-5085(83)90022-7