Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients

摘要: Abstract Four forms of piecemeal necrosis—biliary, lymphocytic, ductular, and fibrotic—were identified in 605 liver biopsy specimens from 209 patients with primary biliary cirrhosis. Whereas lymphocytic necrosis, often associated lobular hepatitis, was most common stages 2 3 the classical histologic staging, necrosis frequent all stages, except stage 1, fibrotic form appeared to be a late, mainly cirrhotic feature. In 77% cholestatic features predominated, whereas hepatitic changes producing some overlap chronic active hepatitis occurred remaining patients. These patterns tended maintained throughout course disease. Large hypocellular scars found 36% 59% 4 specimens, respectively, characteristic feature The prevalence assessed. analysis sequential those who died showed that transformation, increasing cholestasis (in particular prominent hyaline inclusions), abundance coarse collagen bundles, "halo" formation at margins fibrous septa were poor prognosis. We unable show presence granulomas is more favorable