Correlation of C0 and C2 Levels With Lipid Profiles in Adolescent Renal Transplant Recipients in the Early and Late Posttransplant Periods

摘要: Hyperlipidemia is a frequent complication after renal transplantation. Cyclosporine therapy an important cause of hyperlipidemia. It still controversial whether C0 or C2 the most effective way to monitor blood cyclosporine concentrations guide dosages. We sought evaluate relationship serum lipid levels in early and late posttransplant periods among adolescent transplant recipients. The posttransplantation charts 26 recipients were evaluated retrospectively. Serum (triglyceride total cholesterol) analyzed both (first 6 months) (thereafter) periods. Hypertriglyceridemia hypercholesterolemia defined as above 95th percentile adjusted for age gender. To influence on lipids, we excluded one patient with familial In addition, remaining 25 patients acute rejection when creatinine 2.5 mg/dL, representing chronic allograft nephropathy. Concurrently recorded present only 21 patients. Overall, records 245 visits these incidence hyperlipidemia decreased period, being significant hypercholesterolemia. had strong negative correlation lipids; it was cholesterol period (r=-0.542, P=.005), but weaker whole Thus lipids showed differences during follow-up. C0, other hand, positively correlated all periods, (r=0.293, P=.000) (r=0.196, P=.025). Although not statistically significant, higher hypertriglyceridemic hypercholesterolemic episodes When (789 visits), (P=.013, r=0.198 P=.000, r=0.177, respectively). concluded that has more predictable transplantation