Hypothyroid-like regulation of the pituitary-thyroid axis in stable human immunodeficiency virus infection.

摘要: Thyroid function and regulation were studied in 14 consecutive male outpatients with asymptomatic human immunodeficiency virus (HIV) infection (CDC II/III, n = 8) or AIDS IV, 6) who free of concomitant infections hepatic dysfunction, eight healthy, age- weight-matched controls. Blood was sampled every 10 minutes over 24 hours for measurement thyrotropin (TSH). Thereafter, thyroid hormones TSH responsiveness to thyrotropin-releasing hormone (TRH) measured. Triiodothyronine (T3) thyroxine (T4) did not differ between HIV-infected patients controls, but HIV had lower hormone-binding index ([THBI] patients, 1.01 +/- 0.02; 1.11 0.03; P < .02), (FT4) (94 3 v 110 4, .01), FT4 (11.8 0.4 14.3 pmol/L, reverse triiodothyronine (rT3) values (0.18 0.01 0.26 0.02 nmol/L, .001) higher thyroxine-binding globulin ([TBG] 20 1 16 mg/L, .02) values. Mean 24-hour levels increased (2.39 0.33 1.44 0.16 mU/L, .05), associated mean pulse amplitude TRH. No differences observed HIV-seropositive patients. In conclusion, there is a hypothyroid-like the pituitary-thyroid axis stable infection, which differs distinctly from euthyroid sick syndrome non-HIV-nonthyroidal illnesses.(ABSTRACT TRUNCATED AT 250 WORDS)