A limited sampling strategy for cyclophosphamide pharmacokinetics.

摘要: A limited sampling strategy was developed to estimate the total area under curve of plasma cyclophosphamide concentrations versus time (AUC). The with a training set consisting 29 pharmacokinetic studies in 16 patients who received 1-h i.v. infusions at dosage 1000 mg/m2. by applying stepwise forward multiple regression analysis observed each (independent variables) AUC (dependent variable). It confirmed backward elimination same data set. final strategy, which utilized three points, was: = 40.18C24 + 8.79C4 0.83C1 - 28 (dosage/1000), where C24, C4, and C1 represent 24, 4, 1 h, respectively, is mg/m2 (r 0.98). validated prospectively test 14 11 dosages 300, 600, or 1200 proved highly predictive, correlation coefficient between predicted actual 0.94. also unbiased, mean percentage error (+/- SE) 3.3 +/- 3.6%, precise, absolute 9.3 2.7%. being used multiinstitution trial an effort relate pharmacokinetics, as expressed AUC, toxic therapeutic pharmacodynamic responses drug.