Pharmacodynamics in cancer therapy.

摘要: Our understanding of anticancer pharmacodynamics, and the relationships between pharmacologic measurements clinical effects, has grown markedly in recent years due to advances analytical computational technology. Although methotrexate plasma levels have been empirically used guide leucovorin dosing during high-dose therapy, there no other standard use therapeutic drug monitoring oncology. More recently, investigators attempted titrate precisely dose antineoplastic agents based on previously derived models real-time analysis or tissue concentrations. Studies completed are progress using hexamethylene bisacetamide, etoposide, teniposide, fluorouracil (FUra), cytarabine (ara-C). Future studies will focus optimal sampling strategies, intermediate biochemical end points, combination chemotherapy, modulation by colony-stimulating factors, more sophisticated pharmacodynamic models.