Early Recognition of Hepatocellular Carcinoma Based on Altered Profiles of Alpha-Fetoprotein
作者： Yoshiaki Sato , Keisuke Nakata , Yuji Kato , Masayoshi Shima , Nobuko Ishii
DOI: 10.1056/NEJM199306243282502
关键词: Alpha-fetoprotein 、 Cirrhosis 、 AFP-L3 、 Liter 、 Carcinoma 、 Medicine 、 Hepatocellular carcinoma 、 Lectin 、 Pathology 、 Hepatitis C virus
摘要: Background The sugar-chain structures of circulating alpha-fetoprotein in patients with hepatocellular carcinomas differ from those cirrhosis. We studied the reactivity two lectins, Lens culinaris agglutinin A and erythroagglutinating phytohemagglutinin, to monitor evolution carcinoma Methods Among 361 cirrhosis caused mainly by chronic hepatitis B or C virus infection, 33 base-line serum concentrations ≥ 30 ng per milliliter were found have during a mean follow-up 35 months. lectin-reactive profiles these analyzed compared 32 who had increased followed for at least 24 months but whom did not develop. Results At time tumor detecti...
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