"Hypersynchronisation" by tissue velocity imaging in patients with cardiac amyloidosis
作者： D Bellavia , P A Pellikka , T P Abraham , G B Al-Zahrani , A Dispenzieri
关键词: Diastole 、 Dilated cardiomyopathy 、 Tissue velocity 、 Basal (phylogenetics) 、 Internal medicine 、 Amyloidosis 、 Cardiac amyloidosis 、 Heart failure 、 Medicine 、 Circulatory system 、 Cardiology
摘要: Objective: It is unknown if some patients with cardiac amyloidosis (CA) have mechanical dyssynchrony, as has been demonstrated in ischaemic and dilated cardiomyopathies. The aim of this study was to assess dyssynchrony CA using tissue velocity imaging (TVI) define its usefulness for risk stratification. Design patients: We included 121 primary 37 age-matched sex-matched controls. Patients were divided into two groups: 60 advanced-CA 61 no-advanced-CA, according left ventricular (LV) wall thickness diastolic dysfunction. Dyssynchrony assessment included: (1) atrioventricular (dys), (2) interventricular dys, (3) intraventricular dys assessed longitudinally, the standard deviation time systolic peak (Ts-SD) 12 basal mid level LV segments, (4) radially, difference radial Ts between anteroseptal posterior segments. Outcome: Primary end-point all-cause death. During a median follow-up 13 months there 35 events among patients. Results: Contrary hypothesis, indices reduced compared either no-advanced-CA group or controls (Ts-SD: 12.1 (9.0); 35.1 (18.6); 24.5 (14.1), respectively, p Conclusions: regional timing motion measured by TVI abnormally synchronised advanced-CA. ET reduction plays prominent part process should be considered an essential parameter amyloidosis.
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