Immunological effects of antiretroviral therapy.

摘要: The striking decline in HIV load with highly active antiretroviral combination therapy (HAART) is accompanied by substantial improvements immune function, even patients more advanced disease. These include a general reduction activation increases total CD4 and CD8 cell counts, memory naive T subsets antigen responses to certain opportunistic pathogens. At this time, it appears that HAART-induced function are limited those cells have not yet been completely depleted HIV. Long-term studies needed determine whether complete functional restoration of the repertoire possible. Clinically, HAART improves survival reduces progression Some disorders demonstrate or partial resolution infection malignancy. However, persons subclinical Mycobacterium avium complex cytomegalovirus retinitis chronic hepatitis B virus may sometimes experience acute flares if prophylactic against underlying disorder included regimen.