Low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus–infected persons in the era of highly active antiretroviral therapy

摘要: Objectives Human herpesviruses, e.g., herpes simplex virus (HSV) type 1, Epstein-Barr virus, and cytomegalovirus, appear in saliva at greater frequency persons infected with human immunodeficiency (HIV) than healthy individuals. However, it is not known if varicella zoster (VZV) HSV-2 simultaneously during HIV infection this era of highly active antiretroviral therapy (HAART). The aim study was to investigate the prevalence amounts VZV HIV-infected orally asymptomatic patients. Study design Quantitative polymerase chain reaction used prevalence, quantity, risk, correlations salivary from 59 HIV-seropositive individuals 53 control subjects a case-control cross-sectional study. Seventy-eight percent patients (46 out 59) were taking HAART. Results DNA detected 5.1% (3 HIV-positive group only 1 1.9% (1 53; P = .62). amount expressors low, generally 1.0). either group. In group, shedding occurred those on HAART, but associated oral lesions, specific CD4 + or CD8 T-cell levels, demographic factors. Conclusions Varicella low persons, whereas cohort. HAART does diminish risk for shedding.