Bacterial Resistance to Carbapenems
作者： David M. Livermore
DOI: 10.1007/978-1-4757-9203-4_3
关键词: Cephalosporin 、 Antibiotic resistance 、 Ring (chemistry) 、 Double bond 、 Biapenem 、 Chemistry 、 Imipenem 、 Stereochemistry 、 Carbapenem 、 Meropenem
摘要: Carbapenems differ from conventional penicillins (penams) in having no sulfur atom their 5-membered ring and a double bond between carbons 2 3 (figure 1). Imipenem, the first commercially-available carbapenem, (Merck Sharp Dohme) has been used for nearly 10 years is now being joined by second agent, meropenem (Zeneca/Sumitomo). The development of third biapenem (Lederle) recently discontinued. In contrast to all useful cephalosporins, various experimental carbapenems, these three agents carry substituents β-lactam trans configuration. This factor critical β-lactamase stability carbapenems.1
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