Intradermal rabies pre-exposure vaccination schedules in older travellers: comparison of immunogenicity post-primary course and post-booster.

摘要: BACKGROUND Intradermal (ID) rabies vaccination for pre-exposure prophylaxis (PrEP) has become increasingly popular; however, there is limited evidence about the effectiveness of different ID PrEP schedules in travellers aged > 50 years or their response to boosters. This study aimed compare across vaccine and age groups proportion who were seropositive after (i) primary course (ii) a booster. METHODS Travellers received at travel medicine clinic South Australia from 2000 2016 included. Three examined: 1IDx3 (1 × 0.1 ml on days 0, 7, 21-28), 2IDx2 (2 × 0.1 ml 7) 4IDx1 (4x0.1 ml day 0). The non-standard schedule that been previously explored research settings, but not endorsed by WHO PrEP. Antibody titres ≥0.5 IU/ml considered seropositive. post-booster was estimated each category. Predictors seronegative status examined using multivariable logistic regression models. RESULTS Overall, 835 (median 37.5 years; 37.1% > 50 years) included analyses seropositivity course. Another group 771 45.9 years; 43.5% post-booster. 92.5% (95%CI: 90.5-94.1%) highest with (93.4%; 95%CI: 91.4-95.0%). After adjusting timing serology, odds four times higher (OR 4.17; 1.43-12.18) compared 1IDx3. 98.7% 97.6-99.3%) Of 46 booster ≥3 years PrEP, all CONCLUSIONS In older travellers, most effective, high even many years