SecReT6: a web-based resource for type VI secretion systems found in bacteria
作者： Jun Li , Yufeng Yao , H. Howard Xu , Limin Hao , Zixin Deng
关键词: Biology 、 Computational biology 、 Effector 、 Analysis tools 、 Identification (biology) 、 Bacteria 、 Secretion 、 Gene cluster 、 Microbiology 、 Web application 、 Prokaryotic cells
摘要: Summary SecReT6 (http://db-mml.sjtu.edu.cn/SecReT6/) is an integrated database providing comprehensive information on type VI secretion systems (T6SSs) in bacteria. T6SSs are a class of sophisticated cell contact-dependent apparatuses involved mediating antagonistic or synergistic communications between bacteria and/or and eukaryotes. These have recently been found to be widely distributed among Gram-negative bacterial species. SecReT6 offers unique, readily explorable archive known putative T6SSs, cognate effectors It currently contains data 11 167 core T6SS components mapping 906 498 strains representing 240 species, as well collection over 600 directly relevant references. Also collated archived were 1340 diverse candidate secreted which experimentally shown predicted delivered by into target eukaryotic prokaryotic cells 196 immunity proteins. A broad range gene cluster detection comparative analysis tools accessible via SecReT6, may aid identification proteins around the components. This will regularly updated ensure its ongoing maximal utility relevance scientific research community.
sci-hub.se 参考文章(41)
D. Salomon, L. N. Kinch, D. C. Trudgian, X. Guo, J. A. Klimko, N. V. Grishin, H. Mirzaei, K. Orth, Marker for type VI secretion system effectors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 9271- 9276 ,(2014) , 10.1073/PNAS.1406110111
Alistair B. Russell, S. Brook Peterson, Joseph D. Mougous, Type VI secretion system effectors: poisons with a purpose Nature Reviews Microbiology. ,vol. 12, pp. 137- 148 ,(2014) , 10.1038/NRMICRO3185
Feng Jiang, Nicholas R. Waterfield, Jian Yang, Guowei Yang, Qi Jin, A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells Cell Host & Microbe. ,vol. 15, pp. 600- 610 ,(2014) , 10.1016/J.CHOM.2014.04.010
Nadine S. Lossi, Eleni Manoli, Andreas Förster, Rana Dajani, Tillmann Pape, Paul Freemont, Alain Filloux, The HsiB1C1 (TssB-TssC) Complex of the Pseudomonas aeruginosa Type VI Secretion System Forms a Bacteriophage Tail Sheathlike Structure Journal of Biological Chemistry. ,vol. 288, pp. 7536- 7548 ,(2013) , 10.1074/JBC.M112.439273
Alistair B. Russell, Michele LeRoux, Krisztina Hathazi, Danielle M. Agnello, Takahiko Ishikawa, Paul A. Wiggins, Sun Nyunt Wai, Joseph D. Mougous, Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors Nature. ,vol. 496, pp. 508- 512 ,(2013) , 10.1038/NATURE12074
Lay-Sun Ma, Abderrahman Hachani, Jer-Sheng Lin, Alain Filloux, Erh-Min Lai, Agrobacterium tumefaciens deploys a superfamily of type VI secretion DNase effectors as weapons for interbacterial competition in planta Cell Host & Microbe. ,vol. 16, pp. 94- 104 ,(2014) , 10.1016/J.CHOM.2014.06.002
Alain Filloux, Sophie Bleves, Thibault G. Sana, Abderrahman Hachani, Iwona Bucior, Chantal Soscia, Steve Garvis, Elise Termine, Joanne Engel, The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells Journal of Biological Chemistry. ,vol. 287, pp. 27095- 27105 ,(2012) , 10.1074/JBC.M112.376368
Alistair B. Russell, Pragya Singh, Mitchell Brittnacher, Nhat Khai Bui, Rachel D. Hood, Mike A. Carl, Danielle M. Agnello, Sandra Schwarz, David R. Goodlett, Waldemar Vollmer, Joseph D. Mougous, A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach Cell Host & Microbe. ,vol. 11, pp. 538- 549 ,(2012) , 10.1016/J.CHOM.2012.04.007
Sarah J. Coulthurst, The Type VI secretion system - a widespread and versatile cell targeting system. Research in Microbiology. ,vol. 164, pp. 640- 654 ,(2013) , 10.1016/J.RESMIC.2013.03.017
Frédéric Boyer, Gwennaële Fichant, Jérémie Berthod, Yves Vandenbrouck, Ina Attree, Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics. ,vol. 10, pp. 104- 104 ,(2009) , 10.1186/1471-2164-10-104