Gut peptides and the microbiome: focus on ghrelin.

摘要: Purpose of review In this review, we present recent insights into the role gut microbiota on gastrointestinal (GI) peptide secretion and signalling, with a focus orexigenic hormone, ghrelin. Recent findings Evidence is accumulating suggesting that GI peptides modulated by commensal bacteria in our tract. data shows microbiome impacts ghrelinergic signalling through its metabolites, at level ghrelin receptor (growth hormone secretagogue receptor) highlights concomitant changes circulating levels specific changes. However, mechanisms which interacts including ghrelin, are still largely unknown. Summary The may directly or indirectly influence similar to modulation satiety inducing hormones. Although demonstrating starting emerge, future mechanistic studies needed understand full impact microbiota-ghrelin axis metabolism central-regulated homeostatic non-homeostatic controls food intake.