Compositions of engineered human arginases and methods for treating cancer

摘要: Compositions and methods for the treatment of cancer are described, and, more preferably, to cancers that do not express, or otherwise deficient in, argininosuccinate synthetase, with enzymes deplete L-Arginine in serum. In one embodiment, present invention contemplates an arginase protein, such as a human Arginase I comprising at least amino acid substitution metal cofactor, said protein increased catalytic activity when compared native I.